Bipolar
Disorder or the manic
depressive illness is a mental
disorder that causes depression episodes and manic episodes
(abnormally elevated mood). Earlier it was thought as only a psychiatric
illness with behavioural and mental patterns that causes distress and
impairment of personal functioning. Later with the advancement in the field of Neuropsychiatry
and Neuroimaging techniques and Molecular studies, it has been revealed that
Bipolar Disorder (BD) is a multifactorial brain disorder with radical shifts of
mood.
Although it was long known
that both environmental and genetic factors play an important role,
the cause was not clearly understood. For instance, it has been known that
exposure to high levels of stress for a longer period, especially during
childhood, is responsible for the development of BD. But now, it has been
revealed that which genes need to be blamed. In most cases, no single gene is responsible
for bipolar disorder.
A class of genes known
as Immediate
Early genes (IEGs) respond quickly to environmental stimuli, such as
in stressful condition. It activates other genes that lead to neural plasticity and thus the brain
responses as per the changes in the environment, adapting new experiences. One
type of IEG gene known as EGR3, which normally responds to
environment and stressful stimuli is found to be repressed in the brain of BD patients which suggest that during
stressful condition, the EGR3 in BD patients does not respond to the stimulus
appropriately, making them vulnerable to higher levels of stress and have more
difficulties dealing with stress or adapting to it if compared to healthy
individuals.
Some of the other
candidate genes responsible for bipolar disorder include G72/DAOA, DISC1, NRG1,
TPH2, BDNF, 5-HTT, DAT1 and many more. With the changing lifestyle and increase
in the stressful environment, Bipolar Disorder (BD), along with depression
and schizophrenia has become one of the most serious mental illnesses and one
of the top 20 causes of severe impairment in everyday life. With the current
findings of genes, the exploration has started the role of several of these
mutations in BD pathophysiology using
in vitro and animal models and is
serving as a very promising area in molecular and neuroscience research.
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